Sleuth is a work in progress, like anything else. But as it stands now, it is wired to send commands to the SWCAN bus... assuming you're using a SWCAN modified adapter. If you don't have one, I sell them for $100 each but with no warranty because they are for testing only. I use them with no problem on my car.
The third button you will see on the screenshot below is a "wake up". It actually wakes up the network using some advanced signaling that I built into my latest SWCAN adapter. That means it is able to wake up the car network and send commands, regardless of whether the car is on/off or in between :)